Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:2586171 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25861712586794624putative N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
25867982587697900Coproporphyrinogen III oxidase aerobicQuickGO ontologyBLASTP
25877032588329627Ethanolamine operon regulatory proteinQuickGO ontologyBLASTP
25888012589307507Ethanolamine utilization protein EutKQuickGO ontologyBLASTP
25893142589973660Microcompartments proteinQuickGO ontologyBLASTP
25911562591947792hypothetical proteinBLASTP
25926662593061396HNH endonucleaseQuickGO ontologyBLASTP
25930792593342264hypothetical proteinBLASTP
25933662593908543hypothetical proteinBLASTP
25940052594334330hypothetical proteinBLASTP
25943732594579207hypothetical proteinBLASTP
25948912595376486hypothetical proteinBLASTP
259562825970881461putative amino acid antiporterQuickGO ontologyBLASTP
25971102597931822glutamate racemaseQuickGO ontologyBLASTP
25980502598745696Iso-IS1 ORF2QuickGO ontologyBLASTP
259926426006371374Ethanolamine utilization protein EutAQuickGO ontologyBLASTP
26011032601510408Ethanolamine utilization protein EutSQuickGO ontologyBLASTP
260173126040102280putative multimodular enzymeQuickGO ontologyBLASTP
26042992605249951TransaldolaseQuickGO ontologyBLASTP
260526926072722004Transketolase 2 isozymeQuickGO ontologyBLASTP