Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:2516000 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25160832516706624IS4 ORFQuickGO ontologyBLASTP
251700425184371434sucrose-6-phosphate hydrolaseQuickGO ontologyBLASTP
251844525195031059putative transcriptional regulatorQuickGO ontologyBLASTP
25196712519889219DsdX permeaseQuickGO ontologyBLASTP
251990725212351329D-serine dehydrataseQuickGO ontologyBLASTP
252134325228811539Multidrug resistance protein YQuickGO ontologyBLASTP
252288125240441164Multidrug resistance protein KQuickGO ontologyBLASTP
25244602525074615Positive transcription regulator evgAQuickGO ontologyBLASTP
252540625286723267putative Sensor proteinQuickGO ontologyBLASTP
252872825299121185hypothetical proteinBLASTP
25299472530891945putative transporter yfdVQuickGO ontologyBLASTP
253096125326551695putative oxalyl-CoA decarboxylaseQuickGO ontologyBLASTP
253270925339591251Formyl-coenzyme A transferaseQuickGO ontologyBLASTP
25344722535095624hypothetical proteinBLASTP
25353922535667276hypothetical proteinBLASTP
25357442535986243inner membrane proteinQuickGO ontologyBLASTP
25363392537259921Lipid A biosynthesis lauroyl acyltransferase family proteinQuickGO ontologyBLASTP
25375692537685117hypothetical proteinBLASTP
253775025389881239putative aminotransferaseQuickGO ontologyBLASTP