Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:2225418 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
222541822264701053fructose-bisphosphate aldolase class 1QuickGO ontologyBLASTP
22267072227513807ADP-ribosylglycohydrolase family proteinQuickGO ontologyBLASTP
22275102228475966putative kinaseQuickGO ontologyBLASTP
22284492229195747GntR family transcriptional regulatorQuickGO ontologyBLASTP
22292432230073831putative Lyzozyme M1 14-beta-N-acetylmuramidaseQuickGO ontologyBLASTP
22301292230929801Phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
22309262231714789hydroxyethylthiazole kinaseQuickGO ontologyBLASTP
22319372232209273hypothetical proteinBLASTP
22340182234833816putative type-1 fimbrial proteinQuickGO ontologyBLASTP
223484922373112463putative outer membrane proteinQuickGO ontologyBLASTP
22373272238001675putative fimbrial chaperone yehC precursorQuickGO ontologyBLASTP
22380822238606525putative fimbrial-like proteinQuickGO ontologyBLASTP
22388822239385504IS1 ORF2QuickGO ontologyBLASTP
22394992239660162IS600 ORF2QuickGO ontologyBLASTP
22396762239957282hypothetical proteinBLASTP
224021922413281110putative ATPaseQuickGO ontologyBLASTP
224146022434932034methionyl-tRNA synthetaseQuickGO ontologyBLASTP
22442272245045819IS600 ORF2QuickGO ontologyBLASTP
22450572245674618hypothetical proteinBLASTP
22458972246400504IS1 transposaseQuickGO ontologyBLASTP