Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:2090679 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20898672090754888hypothetical proteinBLASTP
20906792091584906IS2 orfBQuickGO ontologyBLASTP
20911082091446339putative IS2 ORFQuickGO ontologyBLASTP
20915722091772201hypothetical proteinBLASTP
20919712092180210putative outer membrane proteinQuickGO ontologyBLASTP
20926522092927276putative IS1 encoded proteinQuickGO ontologyBLASTP
20930022093505504IS1 ORF2QuickGO ontologyBLASTP
20935512094402852Chaperone protein hchAQuickGO ontologyBLASTP
209451020958681359putative Sensor proteinQuickGO ontologyBLASTP
20958682096650783Two component heavy metal response transcriptional regulator winged helix family precursorQuickGO ontologyBLASTP
20966722097085414TransthyretinQuickGO ontologyBLASTP
20981992098834636membrane protein yedZQuickGO ontologyBLASTP
20990922099742651hypothetical proteinBLASTP
21006682100847180hypothetical proteinBLASTP
21008202101089270putative bacteriophage proteinQuickGO ontologyBLASTP
21011462101814669hypothetical proteinBLASTP
210213021037731644Invasion plasmid antigenQuickGO ontologyBLASTP
21039532104330378putative FOG TransposaseQuickGO ontologyBLASTP
21044732105291819putative IS1 encoded proteinQuickGO ontologyBLASTP
21055822106085504IS1 ORF2QuickGO ontologyBLASTP
21061782106660483hypothetical proteinBLASTP
210672821086771950putative tail proteinQuickGO ontologyBLASTP
21087622109097336hypothetical proteinBLASTP
21090972109453357hypothetical proteinBLASTP
210945321109491497putative sheath proteinQuickGO ontologyBLASTP