Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:1835108 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
183696518379751011putative Zn-dependent alcohol dehydrogenaseQuickGO ontologyBLASTP
18380431838405363Plasmid maintenance system antidote protein XRE familyQuickGO ontologyBLASTP
18386331839286654Formate dehydrogenase-N gamma subunitQuickGO ontologyBLASTP
18392791840163885Formate dehydrogenase nitrate-inducible iron-sulfur subunitQuickGO ontologyBLASTP
18434551844336882hypothetical proteinBLASTP
184459118456911101putative outer membrane porin proteinQuickGO ontologyBLASTP
18464501847439990hypothetical proteinBLASTP
18474461847676231leucine-rich repeat proteinQuickGO ontologyBLASTP
18476131847846234putative IS1 encoded proteinQuickGO ontologyBLASTP
18479211848424504IS1 transposaseQuickGO ontologyBLASTP
18483591848667309hypothetical proteinBLASTP
184888218502701389Nitrite extrusion protein 2QuickGO ontologyBLASTP
18540891855021933Nitrate reductase 1 beta subunitQuickGO ontologyBLASTP
18549991855421423IS91 orfQuickGO ontologyBLASTP
18550651855391327IS91 orfQuickGO ontology
185537618566081233IS91 ORFQuickGO ontologyBLASTP
18568791857601723putative HTH-type transcriptional regulator yncCQuickGO ontologyBLASTP
185774218588721131putative oxidoreductaseQuickGO ontologyBLASTP