Pre_GI Gene

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Host: NC_017319 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017319:192482 Shigella flexneri 2002017 plasmid pSFxv_1, complete sequence

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1924821935701089UDP-sugar hydrolaseQuickGO ontologyBLASTP
193575194525951VirK required for proper localization of IcsA VirG at the surface of bacteriaQuickGO ontologyBLASTP
194590195534945ipid A biosynthesis KDO2-lauroyl-lipid IVA acyltransferaseQuickGO ontologyBLASTP
195688196644957IS630 ORFQuickGO ontologyBLASTP
196656197474819IS600 ORF2QuickGO ontologyBLASTP
197510197812303IS600 ORF1QuickGO ontologyBLASTP
197905198036132TraD proteinQuickGO ontologyBLASTP
198045198443399plasmid maintenance proteinQuickGO ontologyBLASTP
198443198670228plasmid maintenance proteinQuickGO ontologyBLASTP
198752199123372OriT nicking and unwinding proteinQuickGO ontologyBLASTP
1991442005081365OriT nicking and unwinding proteinQuickGO ontologyBLASTP
2005052039543450OriT nicking and unwinding proteinQuickGO ontologyBLASTP
203974204726753F pilin acetylation proteinQuickGO ontologyBLASTP
204730205341612FinO putative fertility inhibition proteinQuickGO ontologyBLASTP
205472205684213hypothetical proteinBLASTP
205868206170303hypothetical proteinBLASTP
206211207029819IS600 ORF2QuickGO ontologyBLASTP
207065207367303IS600 ORF1QuickGO ontologyBLASTP
207489207656168hypothetical proteinBLASTP
207702207911210putative regulatorQuickGO ontologyBLASTP
207950208540591hypothetical proteinBLASTP
208849209040192RepB proteinQuickGO ontologyBLASTP
209331210188858RepAQuickGO ontologyBLASTP
210889211080192hypothetical proteinBLASTP
211310211573264IS1294 transposaseQuickGO ontologyBLASTP
211681212505825IS1294 transposaseQuickGO ontologyBLASTP
212515212703189IS1294 transposaseQuickGO ontologyBLASTP
212849213016168putative transposaseQuickGO ontologyBLASTP
2130342147611728invasion plasmid antigen secreted by the Mxi-Spa secretion machineryQuickGO ontologyBLASTP
215151215417267OspE1QuickGO ontologyBLASTP
215474215665192putative transposaseQuickGO ontologyBLASTP
216256216558303IS600 ORF1QuickGO ontologyBLASTP
216594216782189IS600 ORF2QuickGO ontologyBLASTP
216822217172351IS629 ORF2QuickGO ontologyBLASTP
217234217536303IS911 ORF1QuickGO ontologyBLASTP
217583218233651IS911 ORF2QuickGO ontologyBLASTP
218309218674366insertion element IS2 repressor InsAQuickGO ontologyBLASTP
218632219537906insertion element IS2 transposase InsDQuickGO ontologyBLASTP
219764219919156hypothetical proteinBLASTP
219891220475585hypothetical proteinBLASTP
220947221084138hypothetical proteinBLASTP