Pre_GI Gene

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Host: NC_017319 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017319:155958 Shigella flexneri 2002017 plasmid pSFxv_1, complete sequence

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
155958156362405putative reverse transcriptaseQuickGO ontologyBLASTP
156337157140804putative reverse transcriptaseQuickGO ontologyBLASTP
157153157353201IS600 ORF2QuickGO ontologyBLASTP
157749158498750PhoN1 periplasmic non specific acid ohosphataseQuickGO ontologyBLASTP
158668159057390ISSfl1 ORF2QuickGO ontologyBLASTP
159063159287225ISSfl1 ORF1QuickGO ontologyBLASTP
159558159932375hypothetical proteinBLASTP
160121160516396plasmid stable inheritance proteinQuickGO ontologyBLASTP
160516161475960plasmid stable inheritance proteinQuickGO ontologyBLASTP
161915162817903hypothetical proteinBLASTP
162969163094126hypothetical proteinBLASTP
163189163872684hypothetical proteinBLASTP
163873164094222hypothetical proteinBLASTP
164106164291186hypothetical proteinBLASTP
164325164540216hypothetical proteinBLASTP
164585165355771hypothetical proteinBLASTP
165694166347654putative transposaseQuickGO ontologyBLASTP
1664221675131092ISSfl4 ORF3QuickGO ontologyBLASTP
167525168343819IS600 ORF2QuickGO ontologyBLASTP
168379168681303IS600 ORF1QuickGO ontologyBLASTP
168733169290558ISSfl4 ORF3QuickGO ontologyBLASTP
169287169637351ISSfl4 ORF2QuickGO ontologyBLASTP
169634170308675ISSfl4 ORF1QuickGO ontologyBLASTP
171136171774639hypothetical proteinBLASTP
171862172047186IS2 orf1QuickGO ontologyBLASTP
172246172611366insertion element IS2 repressor InsAQuickGO ontologyBLASTP
172569173420852IS2 ORF2QuickGO ontologyBLASTP
173413174042630ISSfl4 ORF1QuickGO ontologyBLASTP
174039174386348ISSfl4 ORF2QuickGO ontologyBLASTP
1744061760071602ISSfl4 ORF3QuickGO ontologyBLASTP
176196176429234IS100 ORF2QuickGO ontologyBLASTP
176481176660180hypothetical proteinBLASTP
176740176991252hypothetical proteinBLASTP