Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:564727 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
564727565587861hypothetical proteinBLASTP
566778567260483hypothetical proteinBLASTP
567436567960525hypothetical proteinBLASTP
567962568552591methyltransferase-like proteinQuickGO ontologyBLASTP
568638568877240hypothetical proteinBLASTP
568898569380483hypothetical proteinBLASTP
5699975712261230putative nuclease SbcCD D subunitQuickGO ontologyBLASTP
574765575313549NUDIX family hydrolaseQuickGO ontologyBLASTP
576142576993852hypothetical proteinBLASTP
577459577824366putative cadmium resistance transcriptional regulator CadCQuickGO ontologyBLASTP
5779005801282229cadmium-exporting ATPaseQuickGO ontologyBLASTP
5813855827611377PhoH family proteinQuickGO ontologyBLASTP
5830295840331005hypothetical proteinBLASTP