Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:3752000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
375221237540381827glucosamine--fructose-6-phosphate aminotransferaseQuickGO ontologyBLASTP
37547043755381678putative transaldolaseQuickGO ontologyBLASTP
37554003756047648haloacid dehalogenaseQuickGO ontologyBLASTP
37560713756856786sorbitol-6-phosphate 2-dehydrogenaseQuickGO ontologyBLASTP
37568773757242366PTS system glucitolsorbitol-specific transporter subunit IIAQuickGO ontologyBLASTP
375745837584621005PTS system glucitolsorbitol-specific transporter subunit IIBCQuickGO ontologyBLASTP
37584753759020546PTS system glucitolsorbitol-specific transporter subunit IICQuickGO ontologyBLASTP
37590633759458396glucitol operon activator proteinQuickGO ontologyBLASTP
375947237605211050putative L-iditol 2-dehydrogenaseQuickGO ontologyBLASTP
37605563761527972putative glucitol operon regulatorQuickGO ontologyBLASTP
376336837638985312-oxoglutarate ferredoxin oxidoreductase subunit gammaQuickGO ontologyBLASTP
376390037646497502-oxoglutarate ferredoxin oxidoreductase subunit betaQuickGO ontologyBLASTP
376464937657191071putative 2-oxoacidacceptor oxidoreductase alpha subunitQuickGO ontologyBLASTP
37657353765944210putative 2-oxoacidacceptor oxidoreductase subunit deltaQuickGO ontologyBLASTP
37660463766708663hypothetical proteinBLASTP
376697137680411071butyrate kinaseQuickGO ontologyBLASTP
37680703768981912phosphate butyryltransferaseQuickGO ontologyBLASTP
376897437700681095butyrate kinaseQuickGO ontologyBLASTP
377016937717671599oxidoreductase FAD-binding proteinQuickGO ontologyBLASTP
377176937730491281hypothetical proteinBLASTP
37730193773867849hypothetical proteinBLASTP