Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:3594000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
359425035955721323branched-chain amino acid transport system II carrier proteinQuickGO ontologyBLASTP
359603135975631533GMP synthaseQuickGO ontologyBLASTP
359757635990301455inosine-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
35994713600220750PP-loop family proteinQuickGO ontologyBLASTP
360029936019241626chaperonin GroELQuickGO ontologyBLASTP
36019543602241288chaperonin 10 kDaQuickGO ontologyBLASTP
36025573603201645integral membrane proteinQuickGO ontologyBLASTP
36031963603666471hypothetical proteinBLASTP
360438236058751494Fe hydrogenaseQuickGO ontologyBLASTP
36060483606965918putative 8-oxoguanine DNA glycosylaseQuickGO ontologyBLASTP
360711536084971383glutamate synthase NADPH homotetramericQuickGO ontologyBLASTP
36085563609386831oxidoreductase NAD-binding proteinQuickGO ontologyBLASTP
36096173610249633transcriptional regulator Rex familyQuickGO ontologyBLASTP
361044936123711923putative drug resistance ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
36127123613476765DNA-binding response regulator LytTr familyQuickGO ontologyBLASTP
361347736151111635sensor histidine kinaseQuickGO ontologyBLASTP
361535436167721419carbon starvation protein CstAQuickGO ontologyBLASTP