Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:3546467 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
354646735476151149putative R-2-hydroxyglutaryl-CoA dehydratase subunitQuickGO ontologyBLASTP
35477273548059333hypothetical proteinBLASTP
35482263548984759ATPase-like proteinQuickGO ontologyBLASTP
35489843549121138hypothetical proteinBLASTP
35491613549703543glycine betaineproline ABC transporter permeasesubstrate-binding proteinQuickGO ontologyBLASTP
35497513550287537hypothetical proteinBLASTP
35503393550557219hypothetical proteinBLASTP
35505663550706141hypothetical protein
35507133551279567hypothetical proteinBLASTP
355130735524071101putative lipoproteinQuickGO ontologyBLASTP
35524253552889465putative lipoproteinQuickGO ontologyBLASTP
35539973554257261hypothetical proteinBLASTP
3555213355528876tRNA-GlyQuickGO ontologyBLASTP
3555532355560776tRNA-GlnQuickGO ontologyBLASTP
3555611355568777tRNA-HisQuickGO ontologyBLASTP
3555948355602376tRNA-GlyQuickGO ontologyBLASTP
3556268355634376tRNA-GlnQuickGO ontologyBLASTP
3556347355642377tRNA-HisQuickGO ontologyBLASTP
35568153557285471phosphodiesteraseQuickGO ontologyBLASTP
35573023557901600RdgBHAM1 family non-canonical purine NTP pyrophosphataseQuickGO ontologyBLASTP
355800535593781374hypothetical proteinBLASTP
35594913559646156hypothetical proteinBLASTP
355964935612111563family 5 extracellular solute-binding proteinQuickGO ontologyBLASTP
356136635627961431glutamyl-tRNAGln amidotransferase subunit BQuickGO ontologyBLASTP
356283235642891458glutamyl-tRNAGln amidotransferase subunit AQuickGO ontologyBLASTP
35643263564613288glutamyl-tRNAGln amidotransferase subunit CQuickGO ontologyBLASTP