Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:33519 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
33519351441626DNA polymerase III subunits gammatauQuickGO ontologyBLASTP
3531235551240hypothetical proteinBLASTP
3558436180597recombination protein RecRQuickGO ontologyBLASTP
3623736500264hypothetical proteinBLASTP
3665036910261sigma-K factor processing regulatory protein BofAQuickGO ontologyBLASTP
3706137753693sugar fermentation stimulation proteinQuickGO ontologyBLASTP
3780938297489NUDIX family hydrolaseQuickGO ontologyBLASTP
3841539137723hypothetical proteinBLASTP
3927140059789iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
4007840239162hypothetical proteinBLASTP
4062241326705thiF domain-containing proteinQuickGO ontologyBLASTP
41409425181110major facilitator superfamily proteinQuickGO ontologyBLASTP
4254743491945GNAT family acetyltransferaseQuickGO ontologyBLASTP
486784875376tRNA-LysQuickGO ontologyBLASTP
4895849554597uracil-DNA glycosylase family proteinQuickGO ontologyBLASTP
551965527176tRNA-LysQuickGO ontologyBLASTP
5561456177564RNA polymerase sigma-70 factor familyQuickGO ontologyBLASTP
56174576161443hypothetical proteinBLASTP
630626313776tRNA-PheQuickGO ontologyBLASTP
6335263537186hypothetical proteinBLASTP
6379263965174hypothetical proteinBLASTP
6420464359156hypothetical proteinBLASTP
6446964582114hypothetical proteinBLASTP
700697014476tRNA-PheQuickGO ontologyBLASTP
7028571028744peptidil-prolyl isomerase family proteinQuickGO ontologyBLASTP
7669877441744NAD-dependent deacetylaseQuickGO ontologyBLASTP
7762778535909LD-carboxypeptidase family proteinQuickGO ontologyBLASTP
7857179512942transporter CorA metal ion transporter familyQuickGO ontologyBLASTP