Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:3178378 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31783783178776399cytidine deaminaseQuickGO ontologyBLASTP
31788603179558699diacylglycerol kinasePAP2 family proteinQuickGO ontologyBLASTP
31795993180099501hypothetical proteinBLASTP
318009631821832088putative hydrolaseQuickGO ontologyBLASTP
318220631833661161putative stage IV sporulation proteinQuickGO ontologyBLASTP
31833563183652297sporulation protein YqfCQuickGO ontologyBLASTP
31837663184212447GatBYqey domain-containing proteinQuickGO ontologyBLASTP
3184255318443117730S ribosomal protein S21QuickGO ontologyBLASTP
31845683184912345HIT family proteinQuickGO ontologyBLASTP
318496931862671299MiaB family RNA modification proteinQuickGO ontologyBLASTP
31862673187025759RsmE family RNA methyltransferaseQuickGO ontologyBLASTP
3187123318806193950S ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
31883693189238870chaperone protein DnaJQuickGO ontologyBLASTP
318965731915281872chaperone protein DnaKQuickGO ontologyBLASTP
31915833192227645co-chaperone GrpEQuickGO ontologyBLASTP
319225431932851032heat-inducible transcription repressor HrcAQuickGO ontologyBLASTP
319348531946271143putative oxygen-independent coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
319465431964621809GTP-binding protein LepAQuickGO ontologyBLASTP
31966033196998396hypothetical proteinBLASTP
319706831981591092stage II sporulation proteinQuickGO ontologyBLASTP
31983333199307975GPR endopeptidaseQuickGO ontologyBLASTP
3199517319978326730S ribosomal protein S20QuickGO ontologyBLASTP