Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2854934 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28549342855755822flagellar hook capping proteinQuickGO ontologyBLASTP
285578528571731389flagellar hook-length control proteinQuickGO ontologyBLASTP
28571792857616438flagellar protein FliJQuickGO ontologyBLASTP
285772028590361317flagellar protein export ATPase FliIQuickGO ontologyBLASTP
286086528624451581fliF flagellar M-ring protein FliFQuickGO ontologyBLASTP
28627872863221435flagellar basal-body rod protein FlgCQuickGO ontologyBLASTP
28633192863720402flagellar basal-body rod protein FlgBQuickGO ontologyBLASTP
28652942865662369hypothetical proteinBLASTP
286620328675251323argininosuccinate lyaseQuickGO ontologyBLASTP
286754728687401194argininosuccinate synthaseQuickGO ontologyBLASTP
28690342869372339hypothetical proteinBLASTP