Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2796000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
279766827988911224hypothetical proteinBLASTP
279904528001001056hypothetical proteinBLASTP
28004392801131693hypothetical proteinBLASTP
280156228030971536peptidase M20M25M40 familyQuickGO ontologyBLASTP
28030882804023936putative magnesium and cobalt transport protein CorAQuickGO ontologyBLASTP
280445228050065555-formyltetrahydrofolate cyclo-ligaseQuickGO ontologyBLASTP
28049992805922924HPrSer kinasephosphataseQuickGO ontologyBLASTP
28063122807049738DedA family proteinQuickGO ontologyBLASTP
28070152807734720DedA family proteinQuickGO ontologyBLASTP
280784328088831041hypothetical proteinBLASTP
28089872809973987hypothetical proteinBLASTP
28099632810664702hypothetical proteinBLASTP
28106642811338675glycosyl transferaseQuickGO ontologyBLASTP
28115252812499975putative thiosulfate sulfurtransferaseQuickGO ontologyBLASTP
28142052814381177hypothetical proteinBLASTP
28144132814811399hypothetical proteinBLASTP
281526528164341170metallo-beta-lactamase family proteinflavodoxinQuickGO ontologyBLASTP
28169312817437507hypothetical proteinBLASTP