Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2288000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
228800622899611956putative tetracycline resistance proteinQuickGO ontologyBLASTP
229378822956591872cadmium-exporting ATPaseQuickGO ontologyBLASTP
22958412296116276hypothetical proteinBLASTP
22962392296529291bacterial microcompartments family proteinQuickGO ontologyBLASTP
22966042297254651propanediol utilization protein PduL-like proteinQuickGO ontologyBLASTP
229725422988521599acetaldehyde dehydrogenaseQuickGO ontologyBLASTP
22988872299771885bacterial microcompartments family proteinQuickGO ontologyBLASTP
22997922300454663ethanolamine utilization protein EutQ-like proteinQuickGO ontologyBLASTP
23006442300907264putative polyhedral organelle formation proteinQuickGO ontologyBLASTP
23009042301206303hypothetical proteinBLASTP
23012842302129846ethanolamine utilization protein EutJ family proteinQuickGO ontologyBLASTP
23022242302829606hypothetical proteinBLASTP
23029482303265318GTP-binding protein EutPPduV familyQuickGO ontologyBLASTP
230480923073492541formate acetyltransferaseQuickGO ontologyBLASTP
230739923088921494aldehyde dehydrogenase family proteinQuickGO ontologyBLASTP
23089302309238309bacterial microcompartments family proteinQuickGO ontologyBLASTP
23092622309558297bacterial microcompartments family proteinQuickGO ontologyBLASTP
23096312309783153hypothetical proteinBLASTP
23098622310128267hypothetical proteinBLASTP
231011523112271113hypothetical proteinBLASTP