Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2114222 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
211236321142251863ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
211422221165222301ABC transporter ATP-binding proteinpermeaseQuickGO ontologyBLASTP
21169362117379444MarR family transcriptional regulatorQuickGO ontologyBLASTP
21174922117932441sperminespermidine acetyltransferaseQuickGO ontologyBLASTP
21182642118845582molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
21188472119074228molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
211935721211741818aldehyde ferredoxin oxidoreductase tungsten-containing proteinQuickGO ontologyBLASTP
21212682121399132hypothetical proteinBLASTP
21235142123954441MOSC domain-containing proteinQuickGO ontologyBLASTP
21239562124435480molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
212545821273621905molybdopterin cofactor synthesisbinding domain proteinQuickGO ontologyBLASTP
212737421286001227molybdopterin biosynthesis enzyme MoeAQuickGO ontologyBLASTP
21286462129113468molybdopterin biosynthesis enzyme MogQuickGO ontologyBLASTP
21293152130007693tungstate ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
21300042130675672tungstate ABC transporter permeaseQuickGO ontologyBLASTP
21306842131535852tungstate ABC transporter tungstate-binding proteinQuickGO ontologyBLASTP
213175521330771323MATE efflux family proteinQuickGO ontologyBLASTP
21330772133274198hypothetical proteinBLASTP
21335162134160645hypothetical proteinBLASTP