Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2054000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20540422054542501hypothetical proteinBLASTP
20545422055534993site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
20556702056491822sporulation transcription factor Spo0AQuickGO ontologyBLASTP
20585692059465897homoserine O-succinyltransferaseQuickGO ontologyBLASTP
205949220607181227homoserine dehydrogenase family proteinQuickGO ontologyBLASTP
206075820620381281O-acetylhomoserine aminocarboxypropyltransferasecysteine synthase family proteinQuickGO ontologyBLASTP
20640522064504453arginine repressorQuickGO ontologyBLASTP
20653512066172822hemolysin AQuickGO ontologyBLASTP
2066194206806218691-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
20680632068620558hypothetical proteinBLASTP
20694232070295873geranyltranstransferaseQuickGO ontologyBLASTP
20704202070635216exodeoxyribonuclease VII small subunitQuickGO ontologyBLASTP
207072920719341206exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
20720052072436432N utilization substance protein BQuickGO ontologyBLASTP
20725752072970396alkaline shock proteinQuickGO ontologyBLASTP
20730522073576525stage III sporulation protein AHQuickGO ontologyBLASTP
20736382074234597stage III sporulation protein AGQuickGO ontologyBLASTP
20743732074963591stage III sporulation protein AFQuickGO ontologyBLASTP
207499920761621164stage III sporulation protein AEQuickGO ontologyBLASTP