Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:2017000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20172262017393168hypothetical protein
20174342017649216hypothetical proteinBLASTP
20176512018010360hypothetical proteinBLASTP
20180262018613588hypothetical proteinBLASTP
20186312019092462hypothetical proteinBLASTP
20190892019910822hypothetical proteinBLASTP
201991720210741158hypothetical proteinBLASTP
20210782021947870hypothetical proteinBLASTP
202196320254633501phage tail tape measure protein TP901 familyQuickGO ontologyBLASTP
20254802025659180hypothetical proteinBLASTP
20257192026063345hypothetical proteinBLASTP
20261252026727603phage major tail protein phi13 familyQuickGO ontologyBLASTP
20267952027151357hypothetical proteinBLASTP
20271622027521360phage protein HK97 gp10 familyQuickGO ontologyBLASTP
20275212027889369putative phage head-tail adaptorQuickGO ontologyBLASTP
20278792028172294phage protein phi-105 familyQuickGO ontologyBLASTP
202825720294891233phage major capsid protein HK97 familyQuickGO ontologyBLASTP
20295412030284744putative Clp proteaseQuickGO ontologyBLASTP
203027720315271251phage portal protein HK97 familyQuickGO ontologyBLASTP
20315712031753183hypothetical proteinBLASTP
203177720335341758putative phage terminase large subunitQuickGO ontologyBLASTP
20335352034020486phage terminase small subunitQuickGO ontologyBLASTP
20341682034635468hypothetical proteinBLASTP
203472820365211794hypothetical proteinBLASTP
20365082036759252hypothetical proteinBLASTP
20368112037332522hypothetical proteinBLASTP
20373542037551198hypothetical proteinBLASTP
20375812037826246hypothetical proteinBLASTP