Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:1700000 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17013871701776390hypothetical proteinBLASTP
17043811704848468MarR family transcriptional regulatorQuickGO ontologyBLASTP
17048741705416543hypothetical proteinBLASTP
17063141706679366glyoxalase family proteinQuickGO ontologyBLASTP
17067081707178471methylated-DNA-protein-cysteine S-methyltransferaseQuickGO ontologyBLASTP
170723517084221188AraC family transcriptional regulatorQuickGO ontologyBLASTP
170858717097951209hypothetical proteinBLASTP
17098201710650831hypothetical proteinBLASTP
171104117121531113putative DNA-binding proteinQuickGO ontologyBLASTP
171649017178931404amino acidpeptide transporterQuickGO ontologyBLASTP
17183301718689360putative iron-dependent repressorQuickGO ontologyBLASTP
17187871719194408hypothetical proteinBLASTP
17195751720429855HDIG domain proteinQuickGO ontologyBLASTP
17205391720724186hypothetical protein
172090117235372637cation-transporting ATPase P-typeQuickGO ontologyBLASTP