Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:1402349 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
140234914038091461putative glyceraldehyde-3-phosphate dehydrogenase NADP-dependentQuickGO ontologyBLASTP
14038491404790942putative thioredoxin reductaseQuickGO ontologyBLASTP
14055621405939378GrdX proteinQuickGO ontologyBLASTP
140603014073161287glycine reductase complex component B subunits alpha and betaQuickGO ontologyBLASTP
14088151409756942thioredoxin-disulfide reductaseQuickGO ontologyBLASTP
14097901410119330thioredoxin family proteinQuickGO ontologyBLASTP
14101971410328132glycine reductase complex component A selenocysteine-containing proteinQuickGO ontologyBLASTP
14103441410673330glycine reductase complex component A selenocysteine-containing proteinQuickGO ontologyBLASTP
141089814124361539glycine reductase complex component C subunit betaQuickGO ontologyBLASTP
141245214136181167glycine reductase complex component C subunit alphaQuickGO ontologyBLASTP
14140451414656612DNA-3-methyladenine glycosylaseQuickGO ontologyBLASTP
141472214169472226restriction endonuclease family proteinQuickGO ontologyBLASTP
14171991417318120hypothetical proteinBLASTP
141738314185941212S-methyl-5-thioribose kinaseQuickGO ontologyBLASTP
141873414197831050S-methyl-5-thioribose-1-phosphate isomeraseQuickGO ontologyBLASTP
14197951419917123hypothetical proteinBLASTP
14199341420581648aldolase class II AraDFucA subfamilyQuickGO ontologyBLASTP
14206251420765141hypothetical proteinBLASTP
14207551421549795DeoR family transcriptional regulatorQuickGO ontologyBLASTP
14218581422067210hypothetical proteinBLASTP