Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:1352506 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
135250613541341629beta-amylaseQuickGO ontologyBLASTP
135489313560951203tyrosine--tRNA ligaseQuickGO ontologyBLASTP
13563811356752372GntR family transcriptional regulatorQuickGO ontologyBLASTP
13567451357617873ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
13576181358367750hypothetical proteinBLASTP
13585041358872369hypothetical proteinBLASTP
13592191360112894hypothetical proteinBLASTP
13601951360548354hypothetical protein
136470513662191515glycosyl hydrolase family proteinQuickGO ontologyBLASTP
136639313676521260putative sensory box-containing diguanylate cyclaseQuickGO ontologyBLASTP
13676031367722120hypothetical proteinBLASTP
13680531368727675L-serine dehydratase iron-sulfur-dependent subunit betaQuickGO ontologyBLASTP
13700561370265210hypothetical proteinBLASTP
13704241370567144hypothetical proteinBLASTP
13708321371416585hypothetical proteinBLASTP
13717341372549816alphabeta hydrolase family proteinQuickGO ontologyBLASTP
13728621373830969dipeptidase family proteinQuickGO ontologyBLASTP
13742231374918696hypothetical proteinBLASTP