Pre_GI Gene

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Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:1280963 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12809631281523561isochorismatase family proteinQuickGO ontologyBLASTP
12816811281992312putative phage shock proteinQuickGO ontologyBLASTP
12820681282532465hypothetical proteinBLASTP
12828091283009201hypothetical proteinBLASTP
12831861284097912hypothetical proteinBLASTP
12842581284836579xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
12875931288015423hypothetical proteinBLASTP
128835912894621104putative transporterQuickGO ontologyBLASTP
12896421289971330MazG family proteinQuickGO ontologyBLASTP
129010812918471740hypothetical proteinBLASTP
12919861292153168hypothetical proteinBLASTP
12924291292569141hypothetical proteinBLASTP
129275112939501200hypothetical proteinBLASTP
12943421294458117ABC transporter substrate-binding proteinQuickGO ontology
12945571295387831ABC transporter substrate-binding proteinQuickGO ontologyBLASTP
129538912970771689ABC transporter permeaseQuickGO ontologyBLASTP
12970401297975936ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
12980401298834795hypothetical protein
129913813003041167hypothetical proteinBLASTP