Pre_GI Gene

Some Help

Host: NC_017297 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017297:122383 Clostridium botulinum F str. 230613 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
122383123021639putative zinc-dependent hydrolaseQuickGO ontologyBLASTP
1234621265783117isoleucine--tRNA ligaseQuickGO ontologyBLASTP
126729127727999LacI family transcriptional regulatorQuickGO ontologyBLASTP
1320691331361068putative mannose-1-phosphate guanylyltransferasemannose-6-phosphate isomeraseQuickGO ontologyBLASTP
134773135579807hypothetical proteinBLASTP
135599136345747hypothetical proteinBLASTP
1365701379521383radical SAM domain-containing proteinQuickGO ontologyBLASTP
1381391394131275putative sugar-binding proteinQuickGO ontologyBLASTP
1407951418051011CotS family spore coat proteinQuickGO ontologyBLASTP
141820142014195hypothetical protein
142041142808768hypothetical proteinBLASTP
142821143807987CotS family spore coat proteinQuickGO ontologyBLASTP
1441871453141128glycosyl transferase family proteinQuickGO ontologyBLASTP