Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:687471 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
687471688007537hypothetical proteinBLASTP
6887136899091197hypothetical proteinBLASTP
6899206909661047M48 peptidase family proteinQuickGO ontologyBLASTP
690975691100126hypothetical proteinBLASTP
6911126922661155hypothetical proteinBLASTP
6922636936511389hypothetical proteinBLASTP
693893694090198hypothetical proteinBLASTP
694292694579288hypothetical proteinBLASTP
6949236962961374hypothetical proteinBLASTP
696268696990723hypothetical proteinBLASTP
6970406983651326modification methylaseQuickGO ontologyBLASTP
698504698767264IS66 family Orf1QuickGO ontologyBLASTP
698793698987195hypothetical proteinBLASTP
6993897007051317hypothetical proteinBLASTP
7007027027652064hypothetical proteinBLASTP
7028997039211023transposase for insertion sequenceQuickGO ontologyBLASTP
703918704700783transposaseIS proteinQuickGO ontologyBLASTP
70475170484999hypothetical proteinBLASTP
705040705351312putative biofilm stress and motility protein AQuickGO ontologyBLASTP
7054237070661644isovaleryl CoA dehydrogenaseQuickGO ontologyBLASTP
707106707294189hypothetical protein
70747470821474123S rRNA guanosine-2-O--methyltransferaseQuickGO ontologyBLASTP
7083337108672535exoribonuclease RQuickGO ontologyBLASTP