Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:601928 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6019286031121185pH-dependent sodiumproton antiporterQuickGO ontologyBLASTP
6033556044941140chaperone protein DnaJQuickGO ontologyBLASTP
6046066065161911molecular chaperone DnaKQuickGO ontologyBLASTP
606890607501612hypothetical proteinBLASTP
6077906102372448hypothetical proteinBLASTP
6103076116951389putative transport proteinQuickGO ontologyBLASTP
611823612410588molybdenum cofactor biosynthesis protein MogAQuickGO ontologyBLASTP
612698613651954transaldolase BQuickGO ontologyBLASTP
614183614959777hypothetical proteinBLASTP
6157766170651290threonine synthaseQuickGO ontologyBLASTP
617069617998930homoserine kinaseQuickGO ontologyBLASTP
6180016204602460bifunctional aspartokinase Ihomoserine dehydrogenase IQuickGO ontologyBLASTP