Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:561402 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5614025639902589Clp ATPaseQuickGO ontologyBLASTP
564008564991984hypothetical proteinBLASTP
5649845668281845type VI secretion proteinQuickGO ontologyBLASTP
566861567304444hypothetical proteinBLASTP
567378567896519hypothetical proteinBLASTP
5680595695701512hypothetical proteinBLASTP
569570570130561hypothetical proteinBLASTP
5701415711541014hypothetical proteinBLASTP
571484572227744hypothetical proteinBLASTP
573450574070621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
574368575201834Dna-J like membrane chaperone proteinQuickGO ontologyBLASTP
5753865777282343LPS assembly outer membrane complex protein LptDQuickGO ontologyBLASTP
5777965791001305peptidyl-prolyl cis-trans isomerase SurAQuickGO ontologyBLASTP
5790845800799964-hydroxythreonine-4-phosphate dehydrogenaseQuickGO ontologyBLASTP
580072580890819KsgADim1 family 16S ribosomal RNA methyltransferaseQuickGO ontologyBLASTP
580904581281378CO2MG2 efflux protein ApaGQuickGO ontologyBLASTP
581298582167870diadenosine tetraphosphataseQuickGO ontologyBLASTP
582257582721465hypothetical proteinBLASTP
582848583069222hypothetical protein
583604584062459transposaseQuickGO ontologyBLASTP