Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:50391 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
48338504822145hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
5039150564174hypothetical protein
50475515751101hypothetical proteinBLASTP
51875529511077murein transglycosylase CQuickGO ontologyBLASTP
5313453406273oxidative damage protection proteinQuickGO ontologyBLASTP
53584547021119adenine DNA glycosylaseQuickGO ontologyBLASTP
5503755756720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
5575656082327hypothetical proteinBLASTP
5619357119927glutaminaseQuickGO ontologyBLASTP
5723157761531hypothetical proteinBLASTP
5776757964198hypothetical proteinBLASTP
58463677959333putative virulence determinantQuickGO ontologyBLASTP
67985691151131HemN family oxidoreductaseQuickGO ontologyBLASTP
6910869701594dITPXTP pyrophosphataseQuickGO ontologyBLASTP
6980170091291hypothetical proteinBLASTP
7008870642555hypothetical proteinBLASTP
7093071751822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
7188472582699hypothetical proteinBLASTP
72602737261125pili biogenesis protein PilT-like ATPaseQuickGO ontologyBLASTP
73835749501116agmatine deiminaseQuickGO ontologyBLASTP
7495475838885putative carbon-nitrogen hydrolaseQuickGO ontologyBLASTP
7601876440423Holliday junction resolvase-like proteinQuickGO ontologyBLASTP
7644077003564hypothetical proteinBLASTP