Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:4509918 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45095204509930411prepilin peptidase dependent protein CQuickGO ontologyBLASTP
45099184510388471hypothetical proteinBLASTP
45103854510993609hypothetical proteinBLASTP
45112284512010783transposaseIS proteinQuickGO ontologyBLASTP
451200745130291023transposase for insertion sequenceQuickGO ontologyBLASTP
451304345164563414hypothetical proteinBLASTP
451660745186792073putative TonB-dependent outer membrane receptorQuickGO ontologyBLASTP
451906745202991233peptidase TQuickGO ontologyBLASTP
452037745219331557putative integral membrane efflux proteinQuickGO ontologyBLASTP
452265245244691818putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
45246774525552876putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
452611545279951881putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
4528098453921511118putative autotransporter proteinQuickGO ontologyBLASTP