Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:4363000 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
436327143644641194mannonate dehydrataseQuickGO ontologyBLASTP
43646044365176573elongation factor PQuickGO ontologyBLASTP
436528043665241245tryptophan-specific transport proteinQuickGO ontologyBLASTP
43668994367153255hypothetical proteinBLASTP
43672224368037816putative short chain oxidoreductaseQuickGO ontologyBLASTP
43680484368998951putative D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
436901043701521143hypothetical proteinBLASTP
437050443720001497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
437200443735571554putative carbohydrate kinaseQuickGO ontologyBLASTP
43735774374287711ribose 5-phosphate isomerase AQuickGO ontologyBLASTP
437442743755151089putative periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
437562443771981575putative ABC transport ATP-binding subunitQuickGO ontologyBLASTP
43772344378232999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
43783454378800456ADP-ribose pyrophosphataseQuickGO ontologyBLASTP
437906243801951134bifunctional PTS system fructose-specific transporter subunit IIAHPr proteinQuickGO ontologyBLASTP
438019243811309391-phosphofructokinaseQuickGO ontologyBLASTP
438114543828451701PTS system fructose-specific transporter subunit IIBCQuickGO ontologyBLASTP
43831704383814645putative regulatory proteinQuickGO ontologyBLASTP
43838114384299489hypothetical proteinBLASTP
43848444385320477adhesinQuickGO ontologyBLASTP
43854474386268822chaperone protein PsaBQuickGO ontologyBLASTP