Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:4155143 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41543644155146783transposaseIS proteinQuickGO ontologyBLASTP
415514341561651023transposase for insertion sequenceQuickGO ontologyBLASTP
41561794156355177prophage CP4-57 integraseQuickGO ontologyBLASTP
41567704157087318prophage proteinQuickGO ontologyBLASTP
41570934157407315putative DNA-binding prophage proteinQuickGO ontologyBLASTP
415775641588441089putative regulatory prophage proteinQuickGO ontologyBLASTP
41588414159800960hypothetical proteinBLASTP
41597934160335543putative prophage proteinQuickGO ontologyBLASTP
41603354160535201AlpA family transcriptional regulatorQuickGO ontologyBLASTP
41605284161415888putative DNA-binding prophage proteinQuickGO ontologyBLASTP
416261241642821671hypothetical proteinBLASTP
416433341654211089hypothetical proteinBLASTP
416550041666991200putative prophage integraseQuickGO ontologyBLASTP
41669234167381459transposaseQuickGO ontologyBLASTP
41673714167571201invasinQuickGO ontologyBLASTP
41680164168498483SsrA-binding proteinQuickGO ontologyBLASTP
41686594169093435hypothetical proteinBLASTP
41690864169370285hypothetical proteinBLASTP
41695204169861342outer membrane biogenesis protein BamEQuickGO ontologyBLASTP
416997541716361662recombination and repair proteinQuickGO ontologyBLASTP
41717234172604882inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
41727284173306579heat shock protein GrpEQuickGO ontologyBLASTP
417341441746941281type II citrate synthaseQuickGO ontologyBLASTP
41754044175793390succinate dehydrogenase cytochrome b556 large membrane subunitQuickGO ontologyBLASTP
41757874176134348succinate dehydrogenase cytochrome b556 small membrane subunitQuickGO ontologyBLASTP
417613541779011767succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
41779514178667717succinate dehydrogenase iron-sulfur subunitQuickGO ontologyBLASTP