Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:3948514 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
394851439496801167hypothetical proteinBLASTP
39497353950397663GTP cyclohydrolase IQuickGO ontologyBLASTP
395058139517321152hypothetical proteinBLASTP
39518683952737870putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
395301139541501140alcohol dehydrogenaseQuickGO ontologyBLASTP
39541713955013843putative esteraseQuickGO ontologyBLASTP
39552823955482201hypothetical proteinBLASTP
395556639579262361hypothetical proteinBLASTP
395792839591901263hypothetical proteinBLASTP
39591923959860669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
395987039611801311putative heme-binding proteinQuickGO ontologyBLASTP
396171539629891275molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
39629913963761771molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
396389739651051209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
39651493965802654hypothetical proteinBLASTP
396603039676251596ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
39683083968931624hypothetical proteinBLASTP
396914339705101368hypothetical proteinBLASTP
39705353970987453hypothetical proteinBLASTP
39709873971568582hypothetical proteinBLASTP
397154339726281086hypothetical proteinBLASTP
397259239743551764type VI secretion proteinQuickGO ontologyBLASTP