Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:3535786 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35357863536646861hypothetical proteinBLASTP
353669435377701077hypothetical proteinBLASTP
35378363538126291hypothetical proteinBLASTP
35381073538379273hypothetical proteinBLASTP
35384103538769360hypothetical proteinBLASTP
35387663539065300hypothetical proteinBLASTP
35390823539369288hypothetical proteinBLASTP
35398043540019216hypothetical proteinBLASTP
35400163540321306hypothetical proteinBLASTP
35403023540580279hypothetical proteinBLASTP
35409963541415420hypothetical proteinBLASTP
35414873542446960putative transposaseQuickGO ontologyBLASTP
35426663543010345hypothetical proteinBLASTP
35432273543409183hypothetical proteinBLASTP
35436013543774174hypothetical proteinBLASTP
35445343544761228replicative DNA helicaseQuickGO ontologyBLASTP
35448723545387516hypothetical proteinBLASTP
35453203545544225phage integrase family site specific recombinaseQuickGO ontologyBLASTP
3545685354577086tRNA-LeuQuickGO ontologyBLASTP
3545781354585474tRNA-CysQuickGO ontologyBLASTP
3545907354598276tRNA-GlyQuickGO ontology
35461273546675549phosphatidylglycerophosphate synthetaseQuickGO ontologyBLASTP
354673435485661833excinuclease ABC subunit CQuickGO ontologyBLASTP
35485593549215657response regulatorQuickGO ontologyBLASTP
35498783550102225hypothetical proteinBLASTP
35502303550571342GlpM family proteinQuickGO ontologyBLASTP
35505993550853255hypothetical proteinBLASTP
35511933551744552attachment invasion locus proteinQuickGO ontologyBLASTP
3552431355250676tRNA-LysQuickGO ontologyBLASTP
355285935542831425D-alanineD-serineglycine permeaseQuickGO ontologyBLASTP
355440935555871179N-acetylneuraminic acid mutarotaseQuickGO ontologyBLASTP
35559813556580600NADPHquinone oxidoreductaseQuickGO ontologyBLASTP
355666635579701305hypothetical proteinBLASTP
355798135591111131inactive ferrous ion transporter periplasmic protein EfeOQuickGO ontologyBLASTP