Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:3433804 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34330043433807804hypothetical proteinBLASTP
34338043434775972tRNA mo5U34 methyltransferaseQuickGO ontologyBLASTP
34349683435732765copper homeostasis protein CutCQuickGO ontologyBLASTP
34359643436539576hypothetical proteinBLASTP
343715834388881731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
343911934437294611putative hemolysinQuickGO ontologyBLASTP
344387934455401662putative hemolysin activator proteinQuickGO ontologyBLASTP
344601234475471536virulence factor MviNQuickGO ontologyBLASTP
34478143448725912putative oxidoreductaseQuickGO ontologyBLASTP
34494323450016585ribosomal-protein-S5-alanine N-acetyltransferaseQuickGO ontologyBLASTP
345031034515151206multidrug resistance protein MdtHQuickGO ontologyBLASTP
34516623451769108hypothetical proteinBLASTP
34519103452473564lipoproteinQuickGO ontologyBLASTP
34527703453330561hypothetical proteinBLASTP
34533673454104738putative hydrolaseQuickGO ontologyBLASTP
3454393345448290tRNA-SerQuickGO ontologyBLASTP
345473934558511113transcriptional regulatorQuickGO ontologyBLASTP
34558653456695831glycerophosphoryl diester phosphodiesteraseQuickGO ontologyBLASTP
34569103457236327ABC transporter ATP-binding proteinQuickGO ontologyBLASTP