Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:3290380 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32903803290829450acyl-CoA esteraseQuickGO ontologyBLASTP
329097732921851209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
32922213292868648transporterQuickGO ontologyBLASTP
32932803293576297YciI-like proteinQuickGO ontologyBLASTP
32937993294044246hypothetical proteinBLASTP
32941603294423264hypothetical proteinBLASTP
32946443295183540attachment invasion locus proteinQuickGO ontologyBLASTP
32959063296154249hypothetical proteinBLASTP
329622332976831461cardiolipin synthetaseQuickGO ontologyBLASTP
32978483298171324dsDNA-mimic proteinQuickGO ontologyBLASTP
32984703298685216hypothetical proteinBLASTP
32989823299197216hypothetical protein
329924633002471002oligopeptide ABC transporter ATP-binding protein OppFQuickGO ontologyBLASTP
330024433012451002oligopeptide ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
33012573302162906oligopeptide ABC transporter permease OppCQuickGO ontologyBLASTP
33021813303101921oligopeptide transporter permeaseQuickGO ontologyBLASTP
330318833048251638oligopeptide ABC transporter substrate-binding protein OppAQuickGO ontologyBLASTP
33056623306306645hypothetical proteinBLASTP
330711333097882676bifunctional acetaldehyde-CoAalcohol dehydrogenaseQuickGO ontologyBLASTP
331032833113501023transposase for insertion sequenceQuickGO ontologyBLASTP
33113473312129783transposaseIS proteinQuickGO ontologyBLASTP
33124983313088591thymidine kinaseQuickGO ontologyBLASTP
33138383314248411global DNA-binding transcriptional dual regulator H-NSQuickGO ontologyBLASTP
331468333160291347putative nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP