Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:3286 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
196132891329putative siderophore biosynthesis protein IucDQuickGO ontologyBLASTP
328650341749putative siderophore biosynthesis protein IucCQuickGO ontologyBLASTP
50315981951putative siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
596570351071aerobactin synthetase subunit alphaQuickGO ontologyBLASTP
71287736609aerobactin synthetase subunit alphaQuickGO ontologyBLASTP
787690991224hypothetical proteinBLASTP
90479241195hypothetical proteinBLASTP
938910222834hypothetical proteinBLASTP
10599119751377hypothetical proteinBLASTP
1253713280744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
1326113911651N-acylhomoserine lactone synthase YspIQuickGO ontologyBLASTP
1509115741651hypothetical proteinBLASTP
1619216587396putative lipoproteinQuickGO ontologyBLASTP
1664916918270insertion element proteinQuickGO ontologyBLASTP
1709217463372hypothetical proteinBLASTP
1750617661156hypothetical proteinBLASTP
1886319363501hypothetical proteinBLASTP
19412209501539hypothetical proteinBLASTP
20962223141353hypothetical proteinBLASTP
2231122997687hypothetical proteinBLASTP
22997247331737OmpAMotB domain-containing proteinQuickGO ontologyBLASTP
2473725228492hypothetical proteinBLASTP
25646282942649Clp ATPaseQuickGO ontologyBLASTP
28291306392349hypothetical proteinBLASTP
30654328762223hypothetical proteinBLASTP
3353133725195hypothetical proteinBLASTP
3375434029276insertion sequence proteinQuickGO ontologyBLASTP
3495035585636hypothetical proteinBLASTP
35601378982298putative kinaseQuickGO ontologyBLASTP
3788538652768hypothetical proteinBLASTP
3874839023276insertion sequence proteinQuickGO ontologyBLASTP
3907739445369insertion sequence proteinQuickGO ontologyBLASTP