Pre_GI Gene

Some Help

Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:3192817 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
319281731944571641AMP nucleosidaseQuickGO ontologyBLASTP
31941843194738555taurine ATP-binding component of a transport systemQuickGO ontologyBLASTP
31947483195569822putative transport system permeaseQuickGO ontologyBLASTP
319557331966041032hypothetical proteinBLASTP
31970433197393351periplasmic binding proteinLacI transcriptional regulatorQuickGO ontologyBLASTP
31975373198007471hypothetical proteinBLASTP
319807131990871017HTH-type transcriptional regulator GalRQuickGO ontologyBLASTP
31996473199844198hypothetical proteinBLASTP
320037832016221245putative phage-related secreted proteinQuickGO ontologyBLASTP
320162232026471026putative phage-related membrane proteinQuickGO ontologyBLASTP
32026513202938288putative phage-related membrane proteinQuickGO ontologyBLASTP
320295132046631713hypothetical proteinBLASTP
32047283204961234putative phage-related membrane proteinQuickGO ontologyBLASTP
32049973205248252putative phage-related membrane proteinQuickGO ontology
32052513205568318hypothetical proteinBLASTP
320558032066321053hypothetical proteinBLASTP
32068043207250447hypothetical proteinBLASTP
32073473207754408hypothetical protein
32077793208039261hypothetical protein
320841732097091293putative voltage-gated ClC-type chloride channel ClcBQuickGO ontologyBLASTP
32098323210500669putative dithiobiotin synthetaseQuickGO ontologyBLASTP
321072432119411218putative ROK family transcriptional regulatorQuickGO ontologyBLASTP
32121553212754600LysR family transcriptional regulatorQuickGO ontologyBLASTP
321325432143721119hypothetical proteinBLASTP
32147183215692975DNA replication terminus site-binding proteinQuickGO ontologyBLASTP
321577232171691398fumarate hydrataseQuickGO ontologyBLASTP