Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2941938 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29419382942441504DNA starvationstationary phase protection protein DpsQuickGO ontologyBLASTP
29426982943474777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
29434972943994498hypothetical proteinBLASTP
29440102944897888threonine and homoserine efflux systemQuickGO ontologyBLASTP
29453022945826525outer membrane protein XQuickGO ontologyBLASTP
29461422947080939hypothetical proteinBLASTP
29473182947860543hypothetical proteinBLASTP
29480562948724669hypothetical proteinBLASTP
294930729505331227putative zinc-binding dehydrogenaseQuickGO ontologyBLASTP
29507082951625918sugar binding proteinQuickGO ontologyBLASTP
295166529531551491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
29531522954144993putative sugar transport system permeaseQuickGO ontologyBLASTP
295427729552811005LacI family transcriptional regulatorQuickGO ontologyBLASTP
29555282956469942LysR family transcriptional regulatorQuickGO ontologyBLASTP
295657229576571086tartrate dehydrogenaseQuickGO ontologyBLASTP
29577262957908183hypothetical proteinBLASTP
295827429599201647putative transporterQuickGO ontologyBLASTP
296003729611611125putative dioxygenase subunit alphaQuickGO ontologyBLASTP
29612572962222966putative dioxygenase subunit betaQuickGO ontologyBLASTP
296287429645621689putative hemolysin activator proteinQuickGO ontologyBLASTP
296471829723137596putative hemolysinQuickGO ontologyBLASTP
29723152972824510hypothetical proteinBLASTP
29729782973121144hypothetical protein
29730692973320252hypothetical proteinBLASTP
297398429760172034hypothetical proteinBLASTP
29760272976224198hypothetical proteinBLASTP
29764272976594168hypothetical proteinBLASTP
29767362977140405hypothetical proteinBLASTP
2977197297729296hypothetical proteinBLASTP
29773002977692393hypothetical proteinBLASTP
29779652978492528hypothetical proteinBLASTP
297875729798361080putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
297993629813241389phosphomannomutaseQuickGO ontologyBLASTP