Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2892000 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28920932892593501NADHubiquinone oxidoreductase subunit AQuickGO ontologyBLASTP
28926952893372678NADH dehydrogenase subunit BQuickGO ontologyBLASTP
289351328953091797bifunctional NADHubiquinone oxidoreductase subunit CDQuickGO ontologyBLASTP
28953122895875564NADH dehydrogenase subunit EQuickGO ontologyBLASTP
289587228972571386NADH dehydrogenase I subunit FQuickGO ontologyBLASTP
289734429000882745NADH dehydrogenase subunit GQuickGO ontologyBLASTP
29000852901062978NADHubiquinone oxidoreductase subunit HQuickGO ontologyBLASTP
29010772901619543NADH dehydrogenase subunit IQuickGO ontologyBLASTP
29016322902177546NADHubiquinone oxidoreductase subunit JQuickGO ontologyBLASTP
29021742902476303NADHubiquinone oxidoreductase subunit KQuickGO ontologyBLASTP
290247329043171845NADHubiquinone oxidoreductase subunit LQuickGO ontologyBLASTP
290435729058891533NADHubiquinone oxidoreductase subunit MQuickGO ontologyBLASTP
290589629073591464NADHubiquinone oxidoreductase subunit NQuickGO ontologyBLASTP
290759529087851191hypothetical proteinBLASTP
29091232909590468hypothetical proteinBLASTP
29096682910204537putative thermosensitive gluconokinaseQuickGO ontologyBLASTP
29102532911017765gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
29110202911142123hypothetical proteinBLASTP
291177629130591284putative lipoproteinQuickGO ontologyBLASTP
29135282914520993putative LacI-family transcriptional regulatorQuickGO ontologyBLASTP