Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2751027 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
275102727526701644phosphoglucomutaseQuickGO ontologyBLASTP
27527432753270528replication initiation regulator SeqAQuickGO ontologyBLASTP
27537652754133369hypothetical proteinBLASTP
27542452754421177hypothetical proteinBLASTP
27544282755189762hypothetical proteinBLASTP
27552412756071831DNA-binding transcriptional regulator ChbRQuickGO ontologyBLASTP
27561202756467348PTS system NN-diacetylchitobiose-specific transporter subunit IIAQuickGO ontologyBLASTP
275663427579951362PTS system NN-diacetylchitobiose-specific transporter subunit IICQuickGO ontologyBLASTP
27580062758323318PTS system NN-diacetylchitobiose-specific transporter subunit IIBQuickGO ontologyBLASTP
27590962759275180hypothetical proteinBLASTP
27593642759744381camphor resistance protein CrcBQuickGO ontologyBLASTP
27597602760164405camphor resistance protein CrcBQuickGO ontologyBLASTP
276026227614371176voltage-gated potassium channelQuickGO ontologyBLASTP
27618262762056231hypothetical protein
27620552762384330acid-resistance proteinQuickGO ontologyBLASTP
276255327636111059putative nickel transport proteinQuickGO ontologyBLASTP
27637602764752993urea transporterQuickGO ontologyBLASTP
27649442765156213urease accessory protein UreDQuickGO ontologyBLASTP
27650772765910834hypothetical proteinBLASTP
27659072766569663urease accessory proteinQuickGO ontologyBLASTP
27666962767382687urease accessory proteinQuickGO ontologyBLASTP
27674042768099696urease accessory protein UreEQuickGO ontologyBLASTP
276839527701131719urease subunit alphaQuickGO ontologyBLASTP
27702032770679477urease subunit betaQuickGO ontologyBLASTP
27706902770992303urease subunit gammaQuickGO ontologyBLASTP