Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2626996 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
262699626293772382putative beta-glucosidaseQuickGO ontologyBLASTP
26295362630066531hypothetical proteinBLASTP
263005926322662208hypothetical proteinBLASTP
26323022632463162hypothetical proteinBLASTP
263271826339261209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
26340052634313309hypothetical proteinBLASTP
26343282634909582hypothetical proteinBLASTP
26352032635385183hypothetical proteinBLASTP
263544426373601917putative autotransporter proteinQuickGO ontologyBLASTP
26381692638408240hypothetical proteinBLASTP
26384472638698252hypothetical proteinBLASTP
26387222639294573hypothetical proteinBLASTP
26393062639707402hypothetical proteinBLASTP
26399402640380441hypothetical proteinBLASTP
26403342640537204hypothetical proteinBLASTP
26406092641190582hypothetical proteinBLASTP
26418632642108246putative regulatorQuickGO ontologyBLASTP
264232126437121392penicillin-binding protein 1CQuickGO ontologyBLASTP
264388726450951209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
264523526464911257PTS system ascorbate-specific transporter subunit IICQuickGO ontologyBLASTP
26466082647156549NUDIX hydrolase YfcDQuickGO ontologyBLASTP
26472252647377153hypothetical protein
26473782647914537phosphodiesteraseQuickGO ontologyBLASTP
26481542648846693hypothetical proteinBLASTP
26492002650108909nucleoside-diphosphate sugar epimeraseQuickGO ontologyBLASTP