Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2560000 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2560071256119811284-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseQuickGO ontologyBLASTP
256126025622971038cytoskeletal protein RodZQuickGO ontologyBLASTP
25622872563036750type IV pilus biogenesisstability protein PilWQuickGO ontologyBLASTP
256319025643861197ribosomal RNA large subunit methyltransferase NQuickGO ontologyBLASTP
25646482565076429mulitfunctional nucleoside diphosphate kinaseapyrimidinic endonuclease3-phosphodiesteraseQuickGO ontologyBLASTP
256540325678232421hypothetical proteinBLASTP
25686012568741141hypothetical protein
256875625726853930putative autotransporter proteinQuickGO ontologyBLASTP
257324325764013159hypothetical proteinBLASTP
25763672576687321hypothetical proteinBLASTP
25768102576911102hypothetical proteinBLASTP
25770252577978954enhanced serine sensitivity protein SseBQuickGO ontologyBLASTP