Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2535732 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
253573225371261395putative proteaseQuickGO ontologyBLASTP
25372632537373111hypothetical protein
25377622538652891lipid kinaseQuickGO ontologyBLASTP
25389192539428510hypothetical proteinBLASTP
25406092541409801bifunctional hydroxy-methylpyrimidine kinase hydroxy-phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
25419312542398468hypothetical proteinBLASTP
25424572542735279hypothetical proteinBLASTP
254274725439551209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
25440462544681636hypothetical proteinBLASTP
25446782545073396hypothetical proteinBLASTP
25451372545532396hypothetical proteinBLASTP
25455702545989420hypothetical proteinBLASTP
25460532546451399hypothetical proteinBLASTP
25464752546954480hypothetical proteinBLASTP
25471142547572459transposaseQuickGO ontologyBLASTP
25475622547717156invasinQuickGO ontologyBLASTP
254794725495241578GMP synthaseQuickGO ontologyBLASTP
25495072549632126hypothetical proteinBLASTP
254970425511671464inosine 5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
255133725527161380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
25528252553049225hypothetical proteinBLASTP
25530982554054957hypothetical proteinBLASTP
255440125558881488GTP-binding protein DerQuickGO ontologyBLASTP