Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2394079 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23940792394954876sulfatethiosulfate transporter permease subunitQuickGO ontologyBLASTP
239494423960351092sulfatethiosulfate transporter subunitQuickGO ontologyBLASTP
23962062397084879cysteine synthase BQuickGO ontologyBLASTP
239732923985611233type III secretion protein GogBQuickGO ontologyBLASTP
23989422399649708putative two-component response regulatorQuickGO ontologyBLASTP
239964624011901545putative two-component sensor histidine kinaseQuickGO ontologyBLASTP
24013262401442117hypothetical proteinBLASTP
240142324028411419hypothetical proteinBLASTP
240354924047301182putative aminotransferaseQuickGO ontologyBLASTP
24047492404955207hypothetical proteinBLASTP
240497624059831008putative peptidaseQuickGO ontologyBLASTP
24061262406323198hypothetical proteinBLASTP
240632024077801461putative permeaseQuickGO ontologyBLASTP
240784024094861647putative pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP
240974124117772037ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
241178124129861206RND family efflux transporter MFP subunitQuickGO ontologyBLASTP