Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2281040 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
228104022830161977DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
22830722283404333hypothetical proteinBLASTP
22834042284009606recombination protein RecRQuickGO ontologyBLASTP
228420722860751869heat shock protein 90QuickGO ontologyBLASTP
22863022286946645adenylate kinaseQuickGO ontologyBLASTP
22870362287998963ferrochelataseQuickGO ontologyBLASTP
22885962289585990CDP-6-deoxy-delta-34-glucoseen reductaseQuickGO ontologyBLASTP
22896232290396774glucose-1-phosphate cytidylyltransferaseQuickGO ontologyBLASTP
22904012290544144hypothetical proteinBLASTP
22905762291475900CDP-glucose 46-dehydrataseQuickGO ontologyBLASTP
229149322928061314lipopolysaccharide biosynthesis protein RfbHQuickGO ontologyBLASTP
22928432293700858paratose synthaseQuickGO ontologyBLASTP
229370122949841284hypothetical proteinBLASTP
22964122297125714glycosyltransferaseQuickGO ontologyBLASTP
229750522986471143putative mannosyltransferaseQuickGO ontologyBLASTP
230011423011271014putative mannosyltransferaseQuickGO ontologyBLASTP
23011432301661519hypothetical proteinBLASTP
23016722302265594GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
230352723049331407mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
23049362305679744glycosyltransferaseQuickGO ontologyBLASTP
230568423070571374phosphomannomutaseQuickGO ontologyBLASTP
230710523082561152LPS O-antigen length regulatorQuickGO ontologyBLASTP
230846023097641305inosineguanosine kinaseQuickGO ontologyBLASTP
230986123115521692putative cationproton antiport proteinQuickGO ontologyBLASTP
231178723130011215putative membrane efflux proteinQuickGO ontologyBLASTP
23132832313540258bifunctional UDP-sugar hydrolase5-nucleotidase periplasmicQuickGO ontologyBLASTP
23135302314321792protein ushA precursorUDP-sugar hydrolase 5-nucleotidaseQuickGO ontologyBLASTP
23143152314938624hypothetical proteinBLASTP
23150422315281240hypothetical proteinBLASTP
23152952315552258hypothetical proteinBLASTP
23156182316097480hypothetical proteinBLASTP
23163612317170810hypothetical proteinBLASTP
231769123205762886copper exporting ATPaseQuickGO ontologyBLASTP