Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:2158839 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21580462158846801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
21588392159468630Na-translocating NADH-quinone reductase subunit DQuickGO ontologyBLASTP
21594752160071597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
216008721613101224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
216135121623731023ApbE family lipoproteinQuickGO ontologyBLASTP
21623862162613228hypothetical proteinBLASTP
21628572163804948hypothetical proteinBLASTP
216416021652181059DNA polymerase IVQuickGO ontologyBLASTP
216533221667921461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
21686672169578912putative LysR family transcriptional regulatorQuickGO ontologyBLASTP
217003821716421605chitin binding domain-containing proteinQuickGO ontologyBLASTP
21718392172144306hypothetical proteinBLASTP
21725712173029459xanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
217315621744031248fermentationrespiration switch proteinQuickGO ontologyBLASTP
21744632174864402DNA-binding transcriptional regulator CrlQuickGO ontologyBLASTP
217504121761441104gamma-glutamyl kinaseQuickGO ontologyBLASTP
217615421774131260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
21777412178499759YcgR family proteinQuickGO ontologyBLASTP
21786972178951255hypothetical proteinBLASTP
21791972179718522hypothetical proteinBLASTP
21804482181005558putative methyltransferaseQuickGO ontologyBLASTP
21812522181776525shikimate kinaseQuickGO ontologyBLASTP
21822662182553288hypothetical proteinBLASTP