Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:1729922 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
172992217344124491insecticidal toxin complexQuickGO ontologyBLASTP
173810217406032502putative insecticial toxinQuickGO ontologyBLASTP
17405441740678135hypothetical proteinBLASTP
17408391741705867LysR family transcriptional regulatorQuickGO ontologyBLASTP
17419661742877912transcriptional regulatorQuickGO ontologyBLASTP
17431801743383204efflux system membrane proteinQuickGO ontologyBLASTP
17433911744326936p-hydroxybenzoic acid efflux subunit AaeAQuickGO ontologyBLASTP
174432817462831956p-hydroxybenzoic acid efflux subunit AaeBQuickGO ontologyBLASTP
174655017476831134succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
17476801748018339succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
17482131748686474ribonucleaseQuickGO ontologyBLASTP
17486911748972282putative ribonuclease inhibitorQuickGO ontologyBLASTP
17490841749632549hypothetical proteinBLASTP
174981317511531341peptidase PmbAQuickGO ontologyBLASTP
17514381752046609hypothetical proteinBLASTP
17522541752640387putative cytochromeQuickGO ontologyBLASTP
17528641753274411nucleoside diphosphate kinase regulatorQuickGO ontologyBLASTP