Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:1631052 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
163105216336552604Clp ATPaseQuickGO ontologyBLASTP
16336521634449798hypothetical proteinBLASTP
16344461635132687hypothetical proteinBLASTP
163513816365261389hypothetical proteinBLASTP
163655816400913534hypothetical proteinBLASTP
16402161640998783hypothetical proteinBLASTP
16413521641528177hypothetical proteinBLASTP
164155016439522403putative Rhs accessory genetic elementQuickGO ontologyBLASTP
16439581644416459hypothetical proteinBLASTP
164440916472732865hypothetical proteinBLASTP
164730116486711371hypothetical proteinBLASTP
16486731649158486hypothetical proteinBLASTP
16492081649399192hypothetical proteinBLASTP
16494751649699225hypothetical proteinBLASTP
16497811650188408putative transcriptional regulatorQuickGO ontologyBLASTP
16503511650527177hypothetical proteinBLASTP
165054916527472199putative Rhs accessory genetic elementQuickGO ontologyBLASTP
16527501653172423hypothetical proteinBLASTP