Pre_GI Gene

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Host: NC_017168 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017168:144000 Yersinia pestis A1122 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1443101458481539hypothetical proteinBLASTP
145845146039195hypothetical proteinBLASTP
146077146190114hypothetical protein
146358146615258hypothetical proteinBLASTP
146662146946285putative colicin immunity proteinQuickGO ontologyBLASTP
1473561495152160hypothetical proteinBLASTP
149485150252768hypothetical proteinBLASTP
150857151636780hypothetical proteinBLASTP
151853152158306hypothetical proteinBLASTP
152241152561321hypothetical proteinBLASTP
152561153241681hypothetical proteinBLASTP
153665154522858hypothetical proteinBLASTP
154898155416519hypothetical proteinBLASTP
1561951571961002sugar-binding periplasmic proteinQuickGO ontologyBLASTP
1576311586351005sugar ABC transporter permeaseQuickGO ontologyBLASTP
1587071602151509sugar transport ATP-binding proteinQuickGO ontologyBLASTP
1607641618641101sugar transport ATP-binding proteinQuickGO ontologyBLASTP
1622271634621236putative sugar-binding proteinQuickGO ontologyBLASTP
1636221649291308putative maltodextrin transport permeaseQuickGO ontologyBLASTP
164941165792852putative maltodextrin permeaseQuickGO ontologyBLASTP
1657971669991203putative galactosidaseQuickGO ontologyBLASTP