Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:945176 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
945176945967792hypothetical proteinBLASTP
9465759476511077membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
9482849494021119AG-specific adenine glycosylaseQuickGO ontologyBLASTP
949737950456720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
950456950782327hypothetical proteinBLASTP
950951951820870glutaminaseQuickGO ontologyBLASTP
951932952462531hypothetical proteinBLASTP
9531659624979333putative virulence determinantQuickGO ontologyBLASTP
9626879637301044coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
963810964403594putative deoxyribonucleotide triphosphate pyrophosphataseQuickGO ontologyBLASTP
964791965345555hypothetical proteinBLASTP
965633966454822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
966587967195609hypothetical proteinBLASTP
9673059684291125hypothetical proteinBLASTP
9685389696531116hypothetical proteinBLASTP
969657970541885putative carbon-nitrogen hydrolaseQuickGO ontologyBLASTP
970721971143423Holliday junction resolvase-like proteinQuickGO ontologyBLASTP
971143971706564hypothetical proteinBLASTP
971822972781960glutathione synthetaseQuickGO ontologyBLASTP